Ultrasound imaging is the most widespread diagnostic imaging modality. In addition to imaging purposes, ultrasound is more and more established in therapeutic applications, ranging from thermal ablation of tumors to ultrasound-assisted drug delivery. Fraunhofer IBMT´s main department “Ultrasound” is one of Europe´s largest research units dedicated to the field of ultrasound. With a staff of more than 40 engineers and scientists, all aspects of ultrasound technologies from simulations, applications, electronics and ultrasound transducer development are addressed.
The topic of the master thesis will be the investigation of the effect of different acoustic signal patterns on cell cultures. Recently, an ultrasound cell applicator allowing to deliver ultrasound of different frequencies, signal patterns and amplitudes to cells has been developed. While it is known, that ultrasound has different effects on cells, e.g. on the membrane integrity, a systematic assessment of the “transfer function” between acoustic stimulus and resulting cellular effect is still lacking. The goal of the thesis will be to use the cell applicator developed by IBMT and to assess the effect on different cell models. For instance, it will be investigated how a transient opening on the blood brain barrier can be achieved with ultrasound. This will be done in a cooperation between Fraunhofer IBMT´s departments “ULTRASOUND” and “MEDICAL BIOTECHNOLOGY”.
The work will be carried out at Fraunhofer IBMT, Sulzbach, Germany.
- Bachelor of Science (B. Sc.) / studies in biology, biotechnology, physics, engineering
- Interests in biological and engineering topics
- Skilled in working with cells models
- Team player with good communication skills
- Result-oriented work approach
- Enthusiasm for work in a multi-disciplinary team
- Language skills: excellent English and/or German
- Literature study to obtain a clear picture of the problem as well as an overview of the current research in the field
- Acoustic characterization of an existing ultrasound cell applicator
- Familiarization with culture methods for the chosen cell model
- Definition of an experimental protocol for assessment of the acoustic effect on cells
- Perform in-vitro studies regarding the acoustic effect on the integrity of the blood brain barrier
- Analysis and interpretation of results
In case of identical qualifications Preference will be given to severely disabled candidates.
We would like to point out that the Chosen Job title also includes the third gender.
The Fraunhofer-Gesellschaft emphasises gender-Independent professional equality.
Fraunhofer is Europe’s largest application-oriented research organization. Our research efforts are geared entirely to people’s needs: health, security, communication, energy and the environment. As a result, the work undertaken by our researchers and developers has a significant impact on people’s lives. We are creative. We shape technology. We design products. We improve methods and techniques. We open up new vistas.
Please send your application, including the reference number (IBMT-2019-25) to:
Fraunhofer-Institut für Biomedizinische Technik IBMT
66280 Sulzbach / Saar
|Kennziffer: IBMT-2019-25||Bewerbungsfrist: 30.09.2020|